POS0965 ARE SMOKING AND ALCOHOL ASSOCIATED WITH PERIPHERAL MUSCULOSKELETAL INVOLVEMENT IN PATIENTS WITH SPONDYLOARTHRITIS? RESULTS FROM THE ASAS-PERSPA STUDY

Background: The harmful effect of smoking on axial spondyloarthritis (axSpA) in relation to radiographic progression is well known, but there are controversies around the role cigarettes other manifestations SpA, such as peripheral involvement. Besides, it has been observed an inverse association between alcohol consumption and disease activity functional impairment 1 , although still unclear its with SpA. Objectives: To evaluate smoking/alcohol intake prevalence articular (arthritis, enthesitis or dactylitis). assess location manifestations. Methods: Patients from cross-sectional ASAS-PerSpA study available data for both status were included. Mixed logistic regressions using manifestation (or location) dependent variable, fixed country random used. interaction was tested. Results: A total 4451 patients either axSpA, SpA Psoriatic Arthritis 59.5% had smoked at any moment 42.7% drinkers. who ever suffered arthritis showed lower frequency habit (OR 0.72, 95%CI 0.63-0.82) 0.82, 0.71-0.94) (Table 1). Among arthritis, associated predominantly upper limbs vs. involvement 0.78, 0.65-0.94), while predominant mono/oligoarticular polyarticular 1.13, 0.94-1.36). also 0.75, 0.63-0.89 OR 0.69, 0.57-0.83, respectively). No found regard dactylitis. At visit, 20.4% current smokers 32.2% consumed alcohol. Current (26.9% 33.6% 0.76, 0.64-0.91) (21.1% 34.6% 0.62-0.96), did not show significant differences. tobacco symptoms past. However, when assessing no drinking limbs. Conclusion: These results suggest that, taking into account country, (arthritis enthesitis), habits. Smoking seems be a oligo/mono Future studies required including influence psoriasis psoriatic relationship References: [1]Zhao S, Thong D, Duffield SJ, et al. Alcohol spondyloarthritis: study. Rheumatol Int 2018. 38(3):375-381. Table 1. Association musculoskeletal Peripheral joint objective signs past Dactylitis Yes 2292 2169 (95%CI)* 765 3696 685 3776 Smoker 887 (38.7%) 1013 (46.7%) 0.72 312 (40.8%) 1588 (43.0%) 0.75 277 (40.4%) 1623 0.89 (0.63-0.82 ) (0.63-0.89 (0.75-1.06) 929 882 (40.7%) 0.82 276 (36.1%) 1535 (41.5%) 0.69 299 (43.6%) 1512 (40.0%) 1.01 (0.71-0.94 (0.57-0.83 (0.84–1.22) *Mixed regression effect. Disclosure Interests: None declared.